骨骼肌干细胞独特型在“休息区”实际上是在努力工作

凯发注册送21

2018-11-08

ResearchersattheUniversityofMichiganhaveidentifiedatypeofskeletalstemcellintherestingzoneoftheepiphysealgrowthplate,whichisaspecialcartilaginoustissueandanimportantdriverfor生长。

NoriakiOno,牙科大学的助理教授,说在休息区骨骼干细胞的定位是因为人们普遍认为干细胞保持安静直到他们需要。

发现细胞,Noriaki和他的同事们使用荧光蛋白标记的细胞在小鼠体内的特定群体和追踪这些细胞的命运,随着时间的推移。 Inthisway,theylearnedhowthecellsbehavedinnativeconditionsthroughoutthelife-cycle,ratherthanonapetridish,othreeimportantthings:Theybecom,Noriakisaid,standwhysometypesofbonedeformitiesandfragilebonediseasescanhappeninsomepatients,,,butNoriakisgroupdiscoveredthatsomecellsintherestingzonewakeupandstarttomakerapidlydividingchondrocytes—cellsthatproducebeautifulcolumns(thatlooklikeastackofpancakes)ayerofthegrowthplate,andsomeofthemactuallygothroughthegrowthplateandintothebonemarrowcavity,creatingosteoblasts(cellsthatmakebone)andbonemarrowstromalcells,lazyanddoingnothing,theyreveryhardworking,platedie,butthesefindingsshowdefiniteevidencethattheysurviveandcontinuetomakebone,:更多信息KojiMizuhashietal,Restingzoneofthegrowthplatehousesauniqueclassofskeletalstemcells,自然(2018)。